Loosely based on the buddy cop film Lethal Weapon 3 starring Mel Gibson and Danny Glover, Lethal Weapon for the Super Nintendo is a one-player action game wherein you assume the role of either Martin Riggs or Roger Murtaugh. Riggs is an impulsive, high-strung Vietnam vet, and Murtaugh is a stable career cop and family man. Whichever character you control, your attack maneuvers consist of kicking and shooting a gun. You must use your gun sparingly, though, as there are a limited number of bullets.

Lethal Weapon is composed of four regular missions and a final case involving a man who is killing police officers. The missions take place aboard a ship, on a subway, in a shopping mall, and within an office complex. Each mission must be carried out within a specified time limit. The game is over when the time runs out, when both Riggs and Murtaugh get killed, or when you have completed all the missions. ~ Brett Alan Weiss, All Game Guide